The teenagers of Disney's most infamous villains return to the Isle of the Lost to recruit a new batch of villainous offspring to join them at Auradon Prep.

Mal struggles with her new celebrity life as the girlfriend of King Ben, putting a spell on her hair making it blonde, and maintaining a princess-like personality that she is uncomfortable with. She admits her issues to her friends Evie, Carlos, and Jay, but they are content with their new lives in Auradon and do not wish to return to the Isle of the Lost. Evie scolds Mal for relying on her mother's spell book to solve her issues. Carlos, wishing to ask Jane to the upcoming Cotillion dance, turns to Mal for help to be honest with her. Mal gives him a sweet that will make him speak the truth, but his dog Dude eats it, magically speaking the truth in English and very frankly as a result.

Teenager Sarah Quinn (Madison Iseman) lives with her mother Kathy (Wendi McLendon-Covey) and younger brother Sonny (Jeremy Ray Taylor) in Wardenclyffe, New York. Sarah is attempting to get into Columbia University by writing an essay about fear. Kathy agrees to watch Sonny’s friend Sam Carter (Caleel Harris) while his father goes out of town.

A young girl discovers a secret map to the dreamworld of Slumberland, and with the help of an eccentric outlaw, she traverses dreams and flees nightmares, with the hope that she will be able to see her late father again.

In a world where people collect Pokémon to do battle, a boy comes across an intelligent talking Pikachu who seeks to be a detective.

A teenager teams up with the daughter of young-adult horror author R.L. Stine after the writer's imaginary demons are set free on the town of Madison, Delaware.